“在伤口上撒盐”有时候是对：提高T细胞活性

盐可以帮助增强对癌症的免疫防御。

Salt could help to boost the immune defense against cancer.

这是由耶拿弗里德里希·席勒大学感染免疫学主席Christina Zielinski教授领导的研究小组的研究结果提出的。

This is suggested by the research findings of a team led by Prof. Dr. Christina Zielinski, who holds the Chair of Infection Immunology at the Friedrich Schiller University in Jena.

该小组在《自然免疫学》杂志上发表了他们的研究结果。

The group presents its findings in Nature Immunology.

氯化钠，俗称“食盐”，在历史上是一种有价值的商品。

Sodium chloride, commonly known as “table salt”, was a valuable commodity in history.

因此，它早就进入了我们的日常语言也就不足为奇了。

It is therefore not surprising that it has long since found its way into our everyday language.

然而，“往伤口上撒盐”这句话可能很快就会被赋予积极的意义，即在癌症治疗中。

However, the phrase “rubbing salt into the wound” could soon be given a positive twist, namely in cancer therapy.

Christina Zielinski领导的研究小组现在已经发现了其中一个因素:钠离子-氯化钠的一种成分-提高抗肿瘤T细胞的效率。

The team led by Christina Zielinski has now discovered one of these factors: Sodium ions – a component of sodium chloride – increase the efficiency of antitumoral T cells.

研究人员能够证明乳腺癌肿瘤比健康组织具有更高的钠浓度，并且当直接环境具有更高的钠浓度时，T细胞对肿瘤的作用特别强。

The researchers were able to show that breast cancer tumors have a higher sodium concentration than healthy tissue and that T cells act particularly strongly against tumors when the immediate environment has a higher sodium concentration.

研究人员发现，盐通过增加细胞对糖和氨基酸的吸收，从而提高了CD8+ T细胞的代谢适应性，从而提高了细胞中的能量产生。

The researchers found that the salt improved the metabolic fitness of the CD8+ T cells by increasing the uptake of sugar and amino acids and thus energy production in the cells.

结果，免疫细胞能够更好地消灭肿瘤细胞，正如细胞培养和小鼠实验所显示的那样。

As a result, the immune cells were better able to eliminate tumor cells, as the experiments on cell cultures and mice have shown.

钠离子增加了T细胞细胞膜上钠钾泵的活性。这导致了膜电位的变化，进而增加了t细胞受体的激活。

Sodium ions increase the activity of the sodium-potassium pump on the cell membrane of T cells.This leads to a change in the membrane potential, which in turn increases the activation of the T-cell receptor.

所以，“在伤口上撒盐”有时候是对的。

So, the expression “rubbing salt into someone’s wound” does not necessarily remain a negative one.