Swipe Left For English News
1
该合作将充分结合Medigene在T细胞受体（TCR）生成和表征研究领域的领先优势，以及药明生物独特的CD3抗体、T细胞衔接子（TCE）技术平台以及专利双抗技术平台WuXiBody™
2
该合作为期三年，可涉及多个TCR项目
中国上海、德国普拉内格/马丁斯里德
2024年8月8日
全球领先的合同研究、开发和生产（CRDMO）服务公司药明生物（WuXi Biologics, 2269.HK）今日宣布与TCR肿瘤免疫治疗生物技术公司Medigene AG（Medigene, FSE: MDG1, Prime Standard）达成一项为期三年、覆盖多个靶点的战略研究服务合作，双方将设计并研究用于治疗难治性肿瘤的TCR介导TCE疗法（TCR-TCEs）。该合作将结合Medigene兼具灵敏性、特异性和安全性（3S）的TCR生成和表征能力，并应用药明生物独特的CD3抗体、行业领先的T细胞衔接子（TCE）技术平台和专利双抗技术平台WuXiBody™，强强联手，加速推进难治性肿瘤疗法的研究进程。
陈智胜博士
首席执行官
药明生物
Medigene是TCR生成和表征研究领域的领导企业，我们很高兴能与其达成合作。此次合作进一步凸显了我们CRDMO商业模式中研究服务的优势，彰显了我们凭借领先技术和可靠服务助力全球合作伙伴加速研发创新产品的承诺。我们相信这一合作将开花结果，为全球癌症患者带来福音。
Selwyn Ho 先生
首席执行官
Medigene
很高兴与药明生物达成本次研究合作，药明生物独特的CD3抗体已经得到广泛验证，结合其领先的WuXiBody™和TCE平台，能够支持我们将TCR应用于包括TCR-TCE在内的新型分子形式，相较于TCR-T疗法，它有望为患者实现更高的临床价值。Medigene在为TCR-T细胞疗法开发潜在同类最佳3S TCR方面的实力有目共睹，我们相信能够将这一能力进一步拓展至非细胞疗法，持续为患者提供更好的治疗方案，为股东创造长期价值。
WuXiBody™是药明生物具有自主知识产权的双特异性抗体技术平台。该平台突破了绝大多数双特异性抗体平台技术瓶颈，具有表达量高、稳定性高、溶解度好、易于纯化等优势，并且能够为每个项目节约6到18个月研发时间并显著降低双特异性抗体生产成本，实现更具成本效益和环境效益的药物开发。WuXiBody™平台几乎可将所有抗体序列用以构建双特异性抗体，并且有望降低免疫原性风险及延长其体内半衰期。WuXiBody™平台还兼具独特的灵活性，可以构建各种不同的价数（如二价、三价或四价双特异性抗体），以满足不同项目的生物学特性需求。
关于药明生物
药明生物（股票代码：2269.HK）是一家全球领先的合同研究、开发和生产（CRDMO）服务公司。公司通过开放式、一体化生物制药能力和技术赋能平台，提供全方位的端到端服务，帮助合作伙伴发现、开发及生产生物药，实现从概念到商业化生产的全过程，加速全球生物药研发进程，降低研发成本，造福病患。
药明生物在中国、美国、爱尔兰、德国和新加坡拥有超过12000名员工。通过药明生物的专业服务团队，以及先进技术和精深洞见，公司为客户提供高效经济的生物药解决方案。截至2023年12月底，药明生物帮助客户研发和生产的综合项目高达698个，其中包括24个商业化生产项目。
药明生物将环境、社会和治理（ESG）视为业务发展和企业精神的重要组成部分，并致力于成为全球生物药CRDMO领域的ESG领导者，例如应用更绿色环保的新一代生物制药技术和能源等引领行业发展。公司成立了由首席执行官领导的ESG委员会，全面落实ESG战略并践行可持续性发展承诺。
更多信息，请访问：www.wuxibiologics.com
关于
Medigene AG
Medigene AG（FSE: MDG1）是一家专注于T细胞受体（TCR）肿瘤免疫疗法的生物技术公司。公司的端到端开发平台能够生成优化的兼具灵敏性、特异性和安全性的TCR，这些TCR具有独特的差异化特征，适用于多种药物分子形式，包括T细胞受体工程化T细胞疗法（TCR-T）、TCR介导的T细胞衔接器（TCE）疗法以及TCR NK细胞疗法等，并广泛应用于公司自有研发管线及合作药物分子研发。
Medigene目前核心在研的药物分子MDG1015是一款治疗多种实体瘤、具有同类最佳潜力的TCR-T疗法。公司自有的端到端平台技术能够增强T细胞克服肿瘤免疫微环境（TME）免疫抑制作用的能力，确保T细胞疗法的安全性、有效性和持久性。MDG1015预计将于2024年第三季度进行IND申报，于2024年第四季度进行CTA申报。
更多信息，请访问www.medigene.com
业务垂询
info@wuxibiologics.com
媒体关系
PR@wuxibiologics.com
WuXi Biologics and Medigene Enter into a Research Collaboration for Off-the-Shelf TCR-Guided T Cell Engagers
1
Partnership leverages Medigene's leadership for T cell receptor (TCR) generation and characterization and WuXi Biologics' unique anti-CD3 mAb, its T cell engager (TCE) platform and proprietary bispecific antibody platform WuXiBody™
2
Collaboration is a three-year and potentially multi-TCR program partnership
Shanghai, Planegg/Martinsried,
Aug. 8, 2024
WuXi Biologics ("WuXi Bio") (2269.HK), a leading global Contract Research, Development and Manufacturing Organization (CRDMO), and Medigene AG (Medigene, FSE: MDG1, Prime Standard) today announced that they have entered into a three-year, multi-target strategic partnership to design and co-research T cell receptor (TCR)-guided T Cell Engagers (TCR-TCEs) for the treatment of difficult-to-treat tumors. The collaboration combines the respective expertise of each company with Medigene's 3S (sensitive, specific and safe) TCR generation and characterization capabilities and WuXi Biologics' unique anti-CD3 mAb, its industry leading TCE platform and proprietary bispecific antibody platform WuXiBody™.
Dr. Chris Chen
Chief Executive Officer
WuXi Biologics
We are excited to partner with Medigene, a leader in TCR generation and characterization. This collaboration will further enhance our research service capabilities in our CRDMO business model and underscore our commitment to enabling global partners to speed up their novel therapy discovery and development with our leading technologies and reliable services. I believe the partnership will be ultimately translated into better treatments for cancer patients worldwide.
Selwyn Ho
CEO
Medigene
We are excited to partner with Medigene, a leader in TCR generation and characterization. This collaboration will further enhance our research service capabilities in our CRDMO business model and underscore our commitment to enabling global partners to speed up their novel therapy discovery and development with our leading technologies and reliable services. I believe the partnership will be ultimately translated into better treatments for cancer patients worldwide.
WuXiBody™ is a leading proprietary bispecific antibody platform developed by WuXi Biologics. It can effectively break through the discovery and CMC barriers for the development of many bispecific antibodies with high expression yield, high stability, good solubility, and easy purification to homogeneity, expedite the process by 6-18 months and significantly reduce manufacturing costs, limitations still faced by many other current bispecific platforms. WuXiBody™ platform enables almost any mAb sequence pairs to be assembled into bispecific constructs, which are expected to have low immunogenicity risk and longer in vivo half-life. WuXiBody™ platform also has a unique structural flexibility, which makes it convenient to build various formats with different combinations of valencies (1+1, 1+2, 2+2) to meet the requirements of different target biology.
About
WuXi Biologics
WuXi Biologics (stock code: 2269.HK) is a leading global Contract Research, Development and Manufacturing Organization (CRDMO) offering end-to-end solutions that enable partners to discover, develop and manufacture biologics – from concept to commercialization – for the benefit of patients worldwide.
With over 12,000 skilled employees in China, the United States, Ireland, Germany and Singapore, WuXi Biologics leverages its technologies and expertise to provide customers with efficient and cost-effective biologics discovery, development and manufacturing solutions. As of December 31, 2023, WuXi Biologics is supporting 698 integrated client projects, including 24 in commercial manufacturing.
WuXi Biologics views Environmental, Social, and Governance (ESG) responsibilities as an integral component of our ethos and business strategy, and we aim to be an ESG leader in the biologics CRDMO sector. Our facilities use next-generation biomanufacturing technologies and clean-energy sources. We have also established an ESG committee led by our CEO to steer the comprehensive ESG strategy and its implementation, enhancing our commitment to sustainability.
For more information about WuXi Biologics, please visit: www.wuxibiologics.com.
About
Medigene AG
Medigene AG (FSE: MDG1) is an immuno-oncology platform company dedicated to developing T cell receptor (TCR)-guided therapies to effectively eliminate cancer. Its End-to-End Platform generates optimal 3S (sensitive, specific and safe) T cell receptors with unique and distinctive attributes that are utilized in multiple therapeutic modalities such as T cell receptor engineered T cell (TCR-T) therapies, TCR-guided T cell engager therapies and TCR-natural killer cell therapies for both its in-house product pipeline and partnering.
Medigene's lead TCR-T program MDG1015 is a potential best-in-class, TCR-T therapy to treat multiple solid tumor indications. The End-to-End Platform technologies enable armoring and enhancing of these T cells to overcome the immunosuppressive tumor microenvironment (TME) and ensure the T cell drug product composition maximizes safety, efficacy and durability of response. Medigene's MDG1015 is on track for IND filing in Q3 2024 and CTA filing in Q4 2024.
For more information, please visit www.medigene.com
Contacts
Business
info@wuxibiologics.com
Media
PR@wuxibiologics.com
注：本信息不构成药明生物的信息披露或投资建议
浙公网安备33011002015279
本网站未发布麻醉药品、精神药品、医疗用毒性药品、放射性药品、戒毒药品和医疗机构制剂的产品信息
收藏
登录后参与评论