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IPO失败,这家肿瘤疫苗biotech公司“借壳上市”!

IPO 癌症疫苗 Biotech公司
细胞基因治疗前沿
2023/01/18
1600



在市场降温,IPO的大门被关闭后,Elicio Therapeutics的这家癌症疫苗Biotech公司找到了上市的办法,找一个便宜的壳,注入资产。

2023年1月17日,Elicio宣布将Angion Biomedica合并。Angion Biomedica是一家总部位于纽约Uniondale的Biotech公司,2021年在纳斯达克上市,当时筹集了1.17亿美元。但是随后Angion经历了一系列试验失败后,停止了所有研发项目,被迫于2022年7月开始寻找“战略替代方案”,包括潜在的合并、反向合并和出售或许可其候选项目等措施。

合并后的公司将以Elicio的名义运营,并专注于开发基于Elicio专有的淋巴结靶向Amphiphile (AMP) 技术的免疫疗法,以治疗癌症和其他疾病。合并后的这家Biotech公司将由首席执行官Robert Connelly领导的Elicio执行团队亲自负责运营。股票代码也会改变:从$ANGN到$ELTX。

Elicio Therapeutics 首席执行官 Robert Connelly

Angion的现有股东将拥有新Biotech公司约34.5%的股份,而Elicio股东将获得另外65.5%的股份。“与Angion的合并恰逢其时,ELI-002现在完成了患者临床研究的第一阶段剂量递增部分,”Connelly 在一份声明中说。合并后公司的主导项目将是ELI-002,一种mKRAS治疗性癌症疫苗,目前正在进行胰腺癌和结直肠癌患者进行1期试验。

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截图来源:药融云全球药物研发数据库

Elicio使用独特的Amphiphile技术,将肽、蛋白质和核酸等免疫调节有效载荷直接输送到淋巴结,以期激发更强的免疫反应。


11月下旬,Elicio在C轮融资筹集了3700万美元,作为与交易的一部分,Angion承诺提供高达1000万美元的过桥贷款。

“Angion团队详细审查了创造股东价值的众多战略选择,与Elicio的这次交易是明确的选择,”将加入Elicio董事会Angion首席执行官Jay Venkatesan表示,“我们看到了AMP平台和ELI-002的巨大潜力,而此时肿瘤学界正在重新发现癌症疫苗的价值。”

Jay Venkatesan

受到合并消息影响,这家Biotech公司——Angion股价盘前大跌20%,目前市值0.3亿美元。



关于Elicio Therapeutics

Elicio Therapeutics是一家临床阶段的Biotech公司,开发用于治疗癌症和其他疾病的新型免疫疗法。通过结合免疫学和免疫疗法的专业知识,Elicio正在设计试验性Amphiphile(AMP)免疫疗法,旨在精确靶向并充分利用淋巴结,而淋巴结是我们体内免疫反应协调的部位。Elicio为一系列侵袭性癌症和感染性疾病设计淋巴结靶向扩增剂、免疫调节剂、佐剂和疫苗。

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截图来源:药融云投融资数据库

Elicio于2021年10月开始在其在实体瘤受试者中开展的1期临床试验AMPLIFY-201中给受试者剂量,该试验是针对kras驱动的癌症的先导AMP疫苗ELI-002。


关于 Angion

Angion Biomedica是一家总部位于纽约的Biotech公司,Angion专注于新型小分子疗法的发现、开发和商业化,以应对纤维化疾病。


总结

2022年12月,mRNA疫苗巨头莫Moderna与默沙东MSD对外宣布,两家公司联合开发的个性化肿癌症苗与PD-1抗体Keytruda联用,可将高危的III、IV期黑色素瘤患者死亡或复发风险降低44%,癌症疫苗研发曙光初现。国内外还有多家Biotech公司布局癌症疫苗,这一块未来潜力很大。


参考资料:
[1] 药融云数据库
[2] https://endpts.com/elicio-cancer-vaccine-angion-reverse-merger/
[3] https://elicio.com/2023/01/elicio-therapeutics-and-angion-enter-into-definitive-merger-agreement/


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*声明:本文由入驻摩熵医药的相关人员撰写或转载,观点仅代表作者本人,不代表摩熵医药的立场。
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