ChiCTR2400087923
尚未开始
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2024-08-07
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Subthreshold depression
The efficacy of an online exercise intervention for improving depressive symptoms among patients with subthreshold depression in primary care: a randomized controlled trial
The efficacy of an online exercise intervention for improving depressive symptoms among patients with subthreshold depression in primary care: a randomized controlled trial
1. Examine the effectiveness of a 12-week online instructor-led exercise intervention (EIM) when compared to usual care control in reducing depressive symptoms among people with subthreshold depression in primary care 2. Examine the effectiveness of a 12-week online instructor-led exercise intervention (EIM) when compared to usual care control in reducing anxiety symptoms and improving quality of life among people with subthreshold depression in primary care
随机平行对照
探索性研究/预试验
Stratified block randomization with random block sizes will be used to enhance balance of gender, anxiety symptoms and level of physical activity at baseline between two arms. The randomisation sequence will be generated by an experienced independent statistician using Random Allocation Software. The sealed randomization code will be stored safely and will be inaccessible to any person involved in the study. The randomization number will not be decoded until the participant is assigned to its corresponding randomization number.
The allocation is concealed from the researchers, research assistants or coordinators who carry out the baseline assessment or recorded the data, and the statistician who carries out the analysis.
Health Services Research Fund
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130
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2024-07-01
2027-07-01
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The inclusion criteria for this study are 1) aged 18 years or above; 2) screened by the Patient Health Questionnaire depression scale (PHQ-9) with results categorized as subthreshold depression, major depression or no depression.；
登录查看The exclusion criteria are 1) dysthymia with subthreshold depressive symptoms that last for 2 years or more; 2) major depression within the past 6 months, lifetime history of psychosis, schizophrenia and bipolar affective disorder, alcohol or substance abuse, presence of serious suicidal risk and medical illness with a prognosis of less than 6 months to live; 3) patients who are taking antidepressants need to be taking the same medications for more than 3 months with good compliance to be eligible to enroll. 4) patients currently enrolled in any form of psychological interventions for any depressive disorders or symptoms and 5) the presence of physical conditions and include the presence of recently diagnosed or uncontrolled cardiovascular diseases or uncontrolled hypertension, metabolic, vascular or neurological conditions.；
登录查看Joint Chinese University of Hong Kong
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触界生物2024-10-24
磐霖资本2024-10-24
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Pharma CMC2024-10-24
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