ChiCTR1900021995
正在进行
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2019-03-19
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青光眼
Retinal Nerve Fiber Layer Optical Texture Signature as a Novel Biomarker for Detection of Glaucoma Progression
Retinal Nerve Fiber Layer Optical Texture Signature as a Novel Biomarker for Detection of Glaucoma Progression
1. To compare the hazard ratios for development of visual field progression upon detection of progressive decline in retinal nerve fiber layer (RNFL) optical texture signature versus upon detection of progressive RNFL thinning 2. To compare the survival distributions between eyes with progressive RNFL thinning and eyes with progressive decline in RNFL optical texture signature 3. To determine the specificities of Trend-based Progression Analysis (TPA) for detection of progressive decline in RNFL optical texture signature and progressive RNFL thinning 4. To measure rates of change of VF mean deviation between eyes with and without progressive decline in RNFL thickness/optical texture signature 5. To measure age-related rates of change of RNFL thickness/optical texture signature 6. To compare the sensitivity and specificity for detection of glaucoma between ROTA and conventional OCT analysis
析因分组（即根据危险因素或暴露因素分组）
其它
N/A
N/A
General Research Fund 2018-19
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539
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2019-04-01
2023-06-30
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The inclusion criteria are: age ≥18 years; best corrected visual acuity (VA) ≥20/40.；
登录查看The exclusion criteria are: IOP >30mmHg; only one eye with functional vision; inability to perform reliable VF; pathological myopia (eyes with axial length≥26mm with lacquer cracks and chorioretinal atrophy); suboptimal quality of OCT images; previous intraocular surgery other than uncomplicated cataract extraction; and diabetic retinopathy/ maculopathy.；
登录查看Research Grant Council, University Grants Committee
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