ChiCTR-IOR-17010526
结束
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2017-01-26
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牙周病
益生菌作爲牙周病輔助治療
益生菌作爲牙周病輔助治療: 隨機、安慰劑平行對照試驗
To assess if a probiotic supplement containing Lactobacillus reuteri provided as adjunct to non-surgical periodontal therapy can improve clinical outcomes as compared to placebo. To assess subgingival and oral microbial community shifts induced by the probiotic supplement containing Lactobacillus reuteri as adjunct to non-surgical periodontal therapy.
随机平行对照
其它
Aneesha Acharya (AA) will generate computerized random number sequence using R programming packages.
Trial participants and assessor will be blinded to treatment allocation group.
香港大學
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28
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2017-02-15
2018-08-15
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Adult patients diagnosed with chronic periodontitis, that is with at least 2 non‐adjacent teeth with probing depth ≥5 mm and evidence of radiographic bone loss, with at least 10 teeth excluding third molars and good systemic health.；
登录查看Pregnant or lactating females. Subjects with antibiotic therapy, probiotics or anti-inflammatory drugs within past 6 months. Radiation therapy in the head and neck area, HIV, Tuberculosis, hepatitis or other infectious diseases or uncontrolled diabetes, ischaemic heart disease, thyroid disorders or psychological problems.；
登录查看香港大學牙醫學院
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