间充质干细胞可为免疫细胞贡献线粒体

由莱布尼茨免疫治疗研究所(LIT)卢卡·加蒂诺尼教授领导的一个国际研究小组开发了一种创新的线粒体转移平台，可以对CD8+ T细胞进行充电，使它们能够克服衰竭，更有效地对抗肿瘤细胞。

An international team of researchers, led by Professor Luca Gattinoni at the Leibniz Institute for Immunotherapy (LIT), has developed an innovative mitochondrial transfer platform to supercharge CD8+ T cells, enabling them to overcome exhaustion and more effectively fight tumor cells.

线粒体是细胞的主要能量来源，对维持免疫细胞功能至关重要，它们的丧失或功能障碍与免疫细胞衰竭密切相关。

Mitochondria, the cell's primary energy sources, are crucial for maintaining immune cell function, and their loss or dysfunction is tightly linked to immune cell exhaustion.

在《细胞》杂志上发表的一项新研究中，Gattinoni教授的研究小组发现在骨髓基质细胞(BMSCs)和T细胞之间有线粒体转移，T细胞是免疫系统的功能分支，负责清除癌细胞和感染细胞。

In a new study published in Cell, Professor Gattinoni’s team discovered that mitochondrial transfer occurs between bone marrow stromal cells (BMSCs) and T cells, the functional arm of the immune system responsible for clearing cancerous and infected cells.

高分辨率成像显示，线粒体穿过被称为纳米管的微小隧道，在细胞之间形成一座桥梁。

High-resolution imaging showed mitochondria travel through tiny tunnels called nanotubes, forming a bridge between the cells.

与不接受线粒体的T细胞相比，接受供体线粒体的T细胞变得超能量，生长更强劲，浸润肿瘤的效率更高，并且表现出更少的衰竭迹象。

T cells that received donor mitochondria became supercharged, expanded more robustly, infiltrated the tumor more efficiently, and showed fewer signs of exhaustion compared to T cells that did not take up mitochondria.

该团队成功地将他们的线粒体转移技术应用于广泛的T细胞治疗平台，包括CAR和TCR修饰的T细胞，以及肿瘤浸润淋巴细胞(TILs)。

The team successfully applied their mitochondrial transfer technique across a broad range of T cell therapy platforms, including CAR and TCR-modified T cells, as well as tumor-infiltrating lymphocytes (TILs).

Original publication

Jeremy G. Baldwin, Christoph Heuser-Loy, Tanmoy Saha, Roland C. Schelker, Dragana Slavkovic-Lukic, Nicholas Strieder, Inmaculada Hernandez-Lopez,... Jacob E. Corn, Matteo Iannacone, Donato Inverso, Michael Rehli, Jessica Fioravanti, Shiladitya Sengupta, Luca Gattinoni; "Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy"; Cell