Issued by:
Guidance Issuing Office
Center for Drug Evaluation and Research

Triethylamine (TEA) is used as catalytic solvent in chemical synthesis (1,2). It is a colourless liquid that is soluble in water, ethanol, carbon tetrachloride, and ethyl ether, and very soluble in acetone, benzene, and chloroform. TEA has a vapour pressure of 54 mmHg (20°C), and has been reported to be irritating to the lung and nasal passage with strong ammoniac odour.

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