ChiCTR2300075841
正在进行
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2023-09-18
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Atrial fibrillation
Relationship between renal function and pharmacogenetics on plasma level of direct oral anticoagulants (DOACs)
The impact of renal function and pharmacogenetics on plasma level of direct oral anticoagulants (DOACs) in Chinese patients with renal impairment
1. Establish the range of peak and trough of DOACs level in Chinese patients 2. Delineate the relationship between plasma DOACs level and renal function in Chinese patients 3. To determine the relationship of plasma direct Xa-inhibitors level and anti-Xa activity (by using LMWH as calibrator) 4. Establish the relationship between bleeding complications and recurrent ischaemic/thromboembolic events and plasma DOACs level 5. Establish the relationship between pharmacogenetic variants and plasma DOACs level as well as the rate of bleeding complications and recurrent ischaemic/thromboembolic events
横断面
其它
Not applicable as it is not a randomized controlled trial
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Department support from Department of Pathology, University of Hong Kong
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400
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2022-01-24
2025-12-31
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1. Age >= 18 years old 2. Receiving any DOACs (dabigatran, rivaroxaban, apixaban and edoxaban) for atrial fibrillation 3. Follow up in out-patient clinic in Queen Mary Hospital；
登录查看1. Age <18 years old 2. Patients who are followed up irregularly in out-patient clinic in Queen Mary Hospital 3. Clinical information is incomplete 4. Non-Chinese；
登录查看Department of Pathology, University of Hong Kong
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