ChiCTR1800016517
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2018-06-06
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Anesthetic effects on cardiovascular, neuromuscular and central nervous systems.
Comparison of TIVA with a balanced anesthesia using propofol and low concentration sevoflurane: A BIS guided study
Comparison of total intravenous anesthesia versus a propofol target controlled infusion combined with low MAC sevoflurane
300007
To compare total intravenous anesthesia (TIVA) to 2 groups of combined propofol and sevoflurane anesthesia under 1 MAC anesthesia to determine which technique could provide more favourable overall outcomes in terms of CVS stability, recovery time, consumption of intravenous anesthetics and postoperative side effects.
随机平行对照
诊断试验新技术
The consented subjects were selected in the outpatient department respecting our inclusion criteria by the chief residents of the respective surgical units. The patients were randomly scattered in a morning and afternoon session according to the surgical list with no specific order in age, sex and BMI.
The process of recruiting started two months before starting the pilot study. We ensured that a maximum of 2 experiments would be carried out per day, one in the morning and the other in the afternoon so that the conditions for proper recording of values would be more comfortable and accurate. Only name , type and order of surgery for each consented patient were collected in the outpatient department by a chief resident and handed over to the operating room charge nurse on a weekly basis. All personal data was hidden to the latter. The list was designed such that no repetition of the same type of surgery would recur daily. The chief-resident participated only in this step of the study. The person conducting the study and anesthesiologist was not in contact with any consented patient until their arrival to the operating room.
天津医科大学总医院
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40
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2016-10-17
2017-07-19
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Aged 20-65 years, with American Society of Anesthesiologists (ASA) I-II physical status, BMI < 30 kg/m2 and due for elective abdominal, gynecological and lower limb surgeries under general anesthesia；
登录查看Uncontrolled hypertension, diabetes, endocrinal disorders, neurological; Disorders including epilepsy, hepatic and renal impairment, neuromuscular disorders, BMI >30kg/m2, History of allergy, pregnant patients, patients on drugs which interfere with neuromuscular relaxants as anticonvulsants and aminoglycosides.；
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