ChiCTR2100048714
尚未开始
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2021-07-13
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Suspected or confirmed infection by methicillin-resistant staphylococcus aureus
Multi-center population pharmacokinetic study of intravenous vancomycin in adults in Hong Kong and development of web-based individual dose optimization interface
Multi-center population pharmacokinetic study of intravenous vancomycin in adults in Hong Kong and development of web-based individual dose optimization interface
1. To develop and validate a model characterizing the population pharmacokinetics of intravenous vancomycin in Hong Kong adults using prospectively collected rich therapeutic drug monitoring data from multiple hospitals under Hospital Authority 2. To develop a web-based interface to enable Bayesian estimates of individual vancomycin exposure and evidence-based optimization of individual empirical and TDM-based dosing regimen 3. To evaluate the clinical utility of the developed interface
历史对照研究
其它
N/A
Not stated
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350
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2021-07-01
2022-08-31
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(1) At least 18 years old; (2) Admitted to one of the following hospitals under Hospital Authority: Pamela Youde Nethersole Eastern Hospital, Ruttonjee and Tang Shiu Kin Hospitals, Queen Mary Hospital, Queen Elizabeth Hospital, Kwong Wah Hospital, United Christian Hospital, Prince of Wales Hospital, Princess Margaret Hospital, or Tuen Mun Hospital; and (3) prescribed intermittent intravenous vancomycin.；
登录查看(1) Documented trypanophobia or hemophobia; (2) Subjects prescribed any form of renal replacement therapy to be started before or during IV vancomycin treatment.；
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